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Rapamycin: Potential Cognitive Enhancer July 1, 2012

Posted by Metabiological in Longevity, Transhumanism.
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Rapamycin has been seeing a lot of attention as a possible inhibitor of aging.  First isolated as a bacterial product from Easter Island (yes, that one) it has consistently proven to be one of the most exciting drugs in the anti-aging field.  How big is it?  The protein it affects is officialy known as mTOR or mammalian Target Of Rapamycin.  TOR incidentaly has also been implcated in the positive effects of fasting on human health and the breakdown and reapsorbtion of old organelles during cellular “housekeeping”.

Now, researchers have discovered another potential benefit of rapamycins use.

“We made the young ones learn, and remember what they learned, better than what is normal,” said Veronica Galvan, Ph.D., assistant professor of physiology at the Barshop Institute for Longevity and Aging Studies, part of the UT Health Science Center. “Among the older mice, the ones fed with a diet including rapamycin actually showed an improvement, negating the normal decline that you see in these functions with age.”  The drug also lowered anxiety and depressive-like behavior in the mice, Dr. Galvan said.

Mice are burrowers that prefer tunnels with walls. To observe behavior, Halloran used an elevated maze of tunnels that led to a catwalk. “All of a sudden the mice are in open space,” Halloran said. “It’s pretty far from the floor for their size, sort of like if a person is hiking and suddenly the trail gets steep. It’s pretty far down and not so comfortable.”

Mice with less anxiety were more curious to explore the catwalk. “We observed that the mice fed with a diet containing rapamycin spent significantly more time out in the open arms of the catwalk than the animals fed with a regular diet,” Halloran said.

The second test measured depressive-like behavior in the rodents. Mice do not like to be held by their tails, which is the way they are moved from cage to cage. Inevitably they struggle to find a way out. “So we can measure how much and how often they struggle as a measure of the motivation they have to get out of an uncomfortable situation,” Dr. Galvan said.

The fact that this improved cognition in young as well as old mice as well as the mood related effects suggests this isn’t a reversal of age related decline one might expect from an anti-aging drug but rather something different going on.  Either way keep an eye on rapamycin.  It’s shaping up to be something special.

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